Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Although RAF kinases are critical for controlling cell growth, their mechanism of activation is incompletely understood. Recently, dimerization was shown to be important for activation. Here we show that the dimer is functionally asymmetric with one kinase functioning as an activator to stimulate ac...

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Bibliografiske detaljer
Main Authors: Hu, Jiancheng, Stites, Edward C., Yu, Haiyang, Germino, Elizabeth, Meharena, Hiruy S., Stork, Philip J. S., Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844432/
https://ncbi.nlm.nih.gov/pubmed/23993095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.046
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