Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Ras dimerization is critical for Raf activation. Here we show that the Ras binding domain of Raf (Raf-RBD) induces robust Ras dimerization at low surface densities on supported lipid bilayers and, to a lesser extent, in solution as observed by size exclusion chromatography and confirmed by SAXS. Com...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Packer, Morgan R., Parker, Jillian A., Chung, Jean K., Li, Zhenlu, Lee, Young Kwang, Cookis, Trinity, Guterres, Hugo, Alvarez, Steven, Hossain, Md Amin, Donnelly, Daniel P., Agar, Jeffrey N., Makowski, Lee, Buck, Matthias, Groves, Jay T., Mattos, Carla
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958358/
https://ncbi.nlm.nih.gov/pubmed/33653954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015648118
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