Raf promotes dimerization of the Ras G-domain with increased allosteric connections

Ras dimerization is critical for Raf activation. Here we show that the Ras binding domain of Raf (Raf-RBD) induces robust Ras dimerization at low surface densities on supported lipid bilayers and, to a lesser extent, in solution as observed by size exclusion chromatography and confirmed by SAXS. Com...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Packer, Morgan R., Parker, Jillian A., Chung, Jean K., Li, Zhenlu, Lee, Young Kwang, Cookis, Trinity, Guterres, Hugo, Alvarez, Steven, Hossain, Md Amin, Donnelly, Daniel P., Agar, Jeffrey N., Makowski, Lee, Buck, Matthias, Groves, Jay T., Mattos, Carla
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2021
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958358/
https://ncbi.nlm.nih.gov/pubmed/33653954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015648118
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