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Flavonol activation defines an unanticipated ligand binding site in the kinase-RNase domain of IRE1
Signaling in the most conserved branch of the endoplasmic reticulum (ER) unfolded protein response (UPR) is initiated by sequence-specific cleavage of the HAC1/XBP1 mRNA by the ER stress-induced kinase-endonuclease IRE1. We have discovered that the flavonol quercetin activates yeast IRE1’s RNase and...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2864793/ https://ncbi.nlm.nih.gov/pubmed/20417606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.04.001 |
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