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Phosphoregulation of Ire1 RNase splicing activity
Ire1 is activated in response to accumulation of misfolded proteins within the endoplasmic reticulum as part of the unfolded protein response (UPR). It is a unique enzyme, possessing both kinase and RNase activity that is required for specific splicing of Xbp1 mRNA leading to UPR activation. How pho...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Pub. Group
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988810/ https://ncbi.nlm.nih.gov/pubmed/24704861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4554 |
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