Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming

Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathway identified to date are suitable for ER proteost...

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Detaylı Bibliyografya
Yayımlandı:Nat Chem Biol
Asıl Yazarlar: Grandjean, Julia M.D., Madhavan, Aparajita, Cech, Lauren, Seguinot, Bryan O., Paxman, Ryan J., Smith, Emery, Scampavia, Louis, Powers, Evan T., Cooley, Christina B., Plate, Lars, Spicer, Timothy P., Kelly, Jeffery W., Wiseman, R. Luke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502540/
https://ncbi.nlm.nih.gov/pubmed/32690944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0584-z
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