Modulating protein quality control

le Plate, Lars, Paxman, Ryan J, Wiseman, R Luke, Kelly, Jeffery W
Foilsithe in eLife (2016)

Blinded potency comparison of transthyretin kinetic stabilizers by subunit exchange in human plasma

le Nelson, Luke T., Paxman, Ryan J., Xu, Jin, Webb, Bill, Powers, Evan T., Kelly, Jeffery W.
Foilsithe in Amyloid (2020)

Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion

le Rius, Bibiana, Mesgarzadeh, Jaleh S., Romine, Isabelle C., Paxman, Ryan J., Kelly, Jeffery W., Wiseman, R. Luke
Foilsithe in Blood Adv (2021)

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

le Blackwood, Erik A., Azizi, Khalid, Thuerauf, Donna J., Paxman, Ryan J., Plate, Lars, Kelly, Jeffery W., Wiseman, R. Luke, Glembotski, Christopher C.
Foilsithe in Nat Commun (2019)

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming

le Grandjean, Julia M.D., Madhavan, Aparajita, Cech, Lauren, Seguinot, Bryan O., Paxman, Ryan J., Smith, Emery, Scampavia, Louis, Powers, Evan T., Cooley, Christina B., Plate, Lars, Spicer, Timothy P., Kelly, Jeffery W., Wiseman, R. Luke
Foilsithe in Nat Chem Biol (2020)

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

le Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W
Foilsithe in eLife (2016)