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Blinded potency comparison of transthyretin kinetic stabilizers by subunit exchange in human plasma
Transthyretin (TTR) tetramer dissociation is rate limiting for aggregation and subunit exchange. Slowing of TTR tetramer dissociation via kinetic stabilizer binding slows cardiomyopathy progression. Quadruplicate subunit exchange comparisons of the drug candidate AG10, and the drugs tolcapone, diflu...
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| Publicado no: | Amyloid |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7952025/ https://ncbi.nlm.nih.gov/pubmed/32811187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13506129.2020.1808783 |
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