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Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A–retinol-binding protein comp...
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Main Authors: | , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386102/ https://ncbi.nlm.nih.gov/pubmed/22645360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121005109 |
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