Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A–retinol-binding protein comp...

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Bibliographische Detailangaben
Hauptverfasser: Bulawa, Christine E., Connelly, Stephen, DeVit, Michael, Wang, Lan, Weigel, Charlotte, Fleming, James A., Packman, Jeff, Powers, Evan T., Wiseman, R. Luke, Foss, Theodore R., Wilson, Ian A., Kelly, Jeffery W., Labaudinière, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386102/
https://ncbi.nlm.nih.gov/pubmed/22645360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121005109
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