Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A–retinol-binding protein comp...

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Hlavní autoři: Bulawa, Christine E., Connelly, Stephen, DeVit, Michael, Wang, Lan, Weigel, Charlotte, Fleming, James A., Packman, Jeff, Powers, Evan T., Wiseman, R. Luke, Foss, Theodore R., Wilson, Ian A., Kelly, Jeffery W., Labaudinière, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386102/
https://ncbi.nlm.nih.gov/pubmed/22645360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121005109
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