Nalaganje...

Semi-Quantitative Models for Identifying Potent and Selective Transthyretin Amyloidogenesis Inhibitors

Rate-limiting dissociation of the tetrameric protein transthyretin (TTR), followed by monomer misfolding and misassembly, appears to cause degenerative diseases in humans known as the transthyretin amyloidoses, based on human genetic, biochemical and pharmacologic evidence. Small molecules that bind...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Connelly, Stephen, Mortenson, David E., Choi, Sungwook, Wilson, Ian A., Powers, Evan T., Kelly, Jeffery W., Johnson, Steven M.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557047/
https://ncbi.nlm.nih.gov/pubmed/28625364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.05.080
Oznake: Označite
Brez oznak, prvi označite!