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Bifunctional Coumarin Derivatives that Inhibit Transthyretin Amyloidogenesis and Serve as Fluorescent Transthyretin Folding Sensors
We describe a coumarin derivative that is non-fluorescent in aqueous buffers and that very selectively binds to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4061458/ https://ncbi.nlm.nih.gov/pubmed/23989101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc44667k |
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