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Towards optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies

To develop potent and highly selective transthyretin (TTR) amyloidogenesis inhibitors, it is useful to systematically optimize the three substructural elements that compose a typical TTR kinetic stabilizer: the two aryl rings and the linker joining them. Herein, we evaluated 40 bisaryl molecules bas...

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書誌詳細
主要な著者: Johnson, Steven M., Connelly, Stephen, Wilson, Ian A., Kelly, Jeffery W.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587341/
https://ncbi.nlm.nih.gov/pubmed/18811132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800435s
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