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Towards optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies
To develop potent and highly selective transthyretin (TTR) amyloidogenesis inhibitors, it is useful to systematically optimize the three substructural elements that compose a typical TTR kinetic stabilizer: the two aryl rings and the linker joining them. Herein, we evaluated 40 bisaryl molecules bas...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587341/ https://ncbi.nlm.nih.gov/pubmed/18811132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800435s |
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