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Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies

Transthyretin (TTR) amyloidogenesis inhibitors are typically composed of two aromatic rings and a linker. We have previously established optimal structures for one aromatic ring and the linker. Herein, we employ a suboptimal linker and an optimal aryl-X substructure to rank order the desirability of...

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Bibliografiske detaljer
Main Authors: Johnson, Steven M., Connelly, Stephen, Wilson, Ian A., Kelly, Jeffery W.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698027/
https://ncbi.nlm.nih.gov/pubmed/19191553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801347s
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