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A Substructure Combination Strategy to Create Potent and Selective Transthyretin Kinetic Stabilizers that Prevent Amyloidogenesis and Cytotoxicity

Transthyretin aggregation-associated proteotoxicity appears to cause several human amyloid diseases. Rate-limiting tetramer dissociation and monomer misfolding of transthyretin (TTR) occur before its aggregation into cross-β-sheet amyloid fibrils. Small molecule binding to and preferential stabiliza...

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Detalhes bibliográficos
Main Authors: Choi, Sungwook, Reixach, Natàlia, Connelly, Stephen, Johnson, Steven M., Wilson, Ian A., Kelly, Jeffery W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818972/
https://ncbi.nlm.nih.gov/pubmed/20043671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja908562q
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