Potent Kinetic Stabilizers that Prevent Transthyretin-mediated Cardiomyocyte Proteotoxicity

The V122I mutation that alters the stability of transthyretin (TTR) affects 3–4% of African Americans and leads to amyloidogenesis and development of cardiomyopathy. In addition, 10–15% of individuals over the age of 65 develop senile systemic amyloidosis (SSA) and cardiac TTR deposits due to wild-t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Alhamadsheh, Mamoun M., Connelly, Stephen, Cho, Ahryon, Reixach, Natàlia, Powers, Evan T., Pan, Dorothy W., Wilson, Ian A., Kelly, Jeffery W., Graef, Isabella A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227540/
https://ncbi.nlm.nih.gov/pubmed/21865539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002473
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados