Potent Kinetic Stabilizers that Prevent Transthyretin-mediated Cardiomyocyte Proteotoxicity

The V122I mutation that alters the stability of transthyretin (TTR) affects 3–4% of African Americans and leads to amyloidogenesis and development of cardiomyopathy. In addition, 10–15% of individuals over the age of 65 develop senile systemic amyloidosis (SSA) and cardiac TTR deposits due to wild-t...

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Main Authors: Alhamadsheh, Mamoun M., Connelly, Stephen, Cho, Ahryon, Reixach, Natàlia, Powers, Evan T., Pan, Dorothy W., Wilson, Ian A., Kelly, Jeffery W., Graef, Isabella A.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227540/
https://ncbi.nlm.nih.gov/pubmed/21865539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002473
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