AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

The misassembly of soluble proteins into toxic aggregates, including amyloid fibrils, underlies a large number of human degenerative diseases. Cardiac amyloidoses, which are most commonly caused by aggregation of Ig light chains or transthyretin (TTR) in the cardiac interstitium and conducting syste...

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Autori principali: Penchala, Sravan C., Connelly, Stephen, Wang, Yu, Park, Miki S., Zhao, Lei, Baranczak, Aleksandra, Rappley, Irit, Vogel, Hannes, Liedtke, Michaela, Witteles, Ronald M., Powers, Evan T., Reixach, Natàlia, Chan, William K., Wilson, Ian A., Kelly, Jeffery W., Graef, Isabella A., Alhamadsheh, Mamoun M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683741/
https://ncbi.nlm.nih.gov/pubmed/23716704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300761110
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