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Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis
Transthyretin (TTR) transports the retinol-binding protein–vitamin A complex and is a minor transporter of thyroxine in blood. Its tetrameric structure undergoes rate-limiting dissociation and monomer misfolding, enabling TTR to aggregate or to become amyloidogenic. Mutations in the TTR gene general...
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| Publicado no: | Neurol Ther |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Healthcare
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4919130/ https://ncbi.nlm.nih.gov/pubmed/26894299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40120-016-0040-x |
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