Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

Transthyretin (TTR) transports the retinol-binding protein–vitamin A complex and is a minor transporter of thyroxine in blood. Its tetrameric structure undergoes rate-limiting dissociation and monomer misfolding, enabling TTR to aggregate or to become amyloidogenic. Mutations in the TTR gene general...

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Veröffentlicht in:Neurol Ther
Hauptverfasser: Coelho, Teresa, Merlini, Giampaolo, Bulawa, Christine E., Fleming, James A., Judge, Daniel P., Kelly, Jeffery W., Maurer, Mathew S., Planté-Bordeneuve, Violaine, Labaudinière, Richard, Mundayat, Rajiv, Riley, Steve, Lombardo, Ilise, Huertas, Pedro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Healthcare 2016
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919130/
https://ncbi.nlm.nih.gov/pubmed/26894299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40120-016-0040-x
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