Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A–retinol-binding protein comp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bulawa, Christine E., Connelly, Stephen, DeVit, Michael, Wang, Lan, Weigel, Charlotte, Fleming, James A., Packman, Jeff, Powers, Evan T., Wiseman, R. Luke, Foss, Theodore R., Wilson, Ian A., Kelly, Jeffery W., Labaudinière, Richard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386102/
https://ncbi.nlm.nih.gov/pubmed/22645360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121005109
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