Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A–retinol-binding protein comp...

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Detalles Bibliográficos
Autores principales: Bulawa, Christine E., Connelly, Stephen, DeVit, Michael, Wang, Lan, Weigel, Charlotte, Fleming, James A., Packman, Jeff, Powers, Evan T., Wiseman, R. Luke, Foss, Theodore R., Wilson, Ian A., Kelly, Jeffery W., Labaudinière, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386102/
https://ncbi.nlm.nih.gov/pubmed/22645360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121005109
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