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Involvement of the IRE1α-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases

The X-box binding protein 1 (XBP1) is not only an important component of the unfolded protein response (UPR), but also an important nuclear transcription factor. Upon endoplasmic reticulum stress, XBP1 is spliced by inositol-requiring enzyme 1 (IRE1), thereby generating functional spliced XBP1 (XBP1...

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Detalhes bibliográficos
Publicado no:DNA Cell Biol
Main Authors: Wu, Rong, Zhang, Qing-Hai, Lu, Yan-Ju, Ren, Kun, Yi, Guang-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281841/
https://ncbi.nlm.nih.gov/pubmed/25216212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2014.2552
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