The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

During skeletal development, osteoblasts produce large amounts of extracellular matrix proteins and must therefore increase their secretory machinery to handle the deposition. The accumulation of unfolded protein in the endoplasmic reticulum induces an adoptive mechanism called the unfolded protein...

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Bibliografiske detaljer
Main Authors: Tohmonda, Takahide, Miyauchi, Yoshiteru, Ghosh, Rajarshi, Yoda, Masaki, Uchikawa, Shinichi, Takito, Jiro, Morioka, Hideo, Nakamura, Masaya, Iwawaki, Takao, Chiba, Kazuhiro, Toyama, Yoshiaki, Urano, Fumihiko, Horiuchi, Keisuke
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090012/
https://ncbi.nlm.nih.gov/pubmed/21415858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.34
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