The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells

BACKGROUND: The endoplasmic reticulum (ER) is a cellular compartment for the biosynthesis and folding of newly synthesized secretory proteins such as insulin. Perturbations to ER homeostasis cause ER stress and subsequently activate cell signaling pathways, collectively known as the Unfolded Protein...

Full description

Saved in:
Bibliographic Details
Main Authors: Lipson, Kathryn L., Ghosh, Rajarshi, Urano, Fumihiko
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241665/
https://ncbi.nlm.nih.gov/pubmed/18286202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001648
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items