Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe

The unfolded protein response (UPR) monitors and adjusts the protein folding capacity of the endoplasmic reticulum (ER). In S. pombe, the ER membrane-resident kinase/endoribonuclease Ire1 utilizes a mechanism of selective degradation of ER-bound mRNAs (RIDD) to maintain homeostasis. We used a geneti...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Guydosh, Nicholas R, Kimmig, Philipp, Walter, Peter, Green, Rachel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2017
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650469/
https://ncbi.nlm.nih.gov/pubmed/28945192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29216
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