RNA surveillance is required for endoplasmic reticulum homeostasis

The unfolded protein response (UPR) is an intracellular stress-signaling pathway that counteracts the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Because defects in ER protein folding are associated with many pathological states, including metabolic, neurologic, genetic, an...

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Bibliografiske detaljer
Main Authors: Sakaki, Kenjiro, Yoshina, Sawako, Shen, Xiaohua, Han, Jaeseok, DeSantis, Melinda R., Xiong, Mon, Mitani, Shohei, Kaufman, Randal J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361423/
https://ncbi.nlm.nih.gov/pubmed/22562797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110589109
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