RNA surveillance is required for endoplasmic reticulum homeostasis

The unfolded protein response (UPR) is an intracellular stress-signaling pathway that counteracts the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Because defects in ER protein folding are associated with many pathological states, including metabolic, neurologic, genetic, an...

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Autori principali: Sakaki, Kenjiro, Yoshina, Sawako, Shen, Xiaohua, Han, Jaeseok, DeSantis, Melinda R., Xiong, Mon, Mitani, Shohei, Kaufman, Randal J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361423/
https://ncbi.nlm.nih.gov/pubmed/22562797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110589109
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