IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

Por Iwawaki, Takao, Akai, Ryoko, Kohno, Kenji
Publicado em 2010

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

Por Iwawaki, Takao, Akai, Ryoko, Yamanaka, Shinya, Kohno, Kenji
Publicado em 2009

Identification of a consensus element recognized and cleaved by IRE1α

Por Oikawa, Daisuke, Tokuda, Mio, Hosoda, Akira, Iwawaki, Takao
Publicado em 2010

A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression

Por Thorp, Edward, Iwawaki, Takao, Miura, Masayuki, Tabas, Ira
Publicado em 2011

A transgenic mouse model for monitoring oxidative stress

Por Oikawa, Daisuke, Akai, Ryoko, Tokuda, Mio, Iwawaki, Takao
Publicado em 2012

Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β

Por Oikawa, Daisuke, Kitamura, Akira, Kinjo, Masataka, Iwawaki, Takao
Publicado em 2012

Microsomal Triglyceride Transfer Protein Inhibition Induces Endoplasmic Reticulum Stress and Increases Gene Transcription via Ire1α/cJun to Enhance Plasma ALT/AST

Por Josekutty, Joby, Iqbal, Jahangir, Iwawaki, Takao, Kohno, Kenji, Hussain, M. Mahmood
Publicado em 2013

Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo

Por Iwawaki, Takao, Akai, Ryoko, Toyoshima, Takae, Takeda, Naoki, Ishikawa, Tomo-o, Yamamura, Ken-ichi
Publicado no Sci Rep (2017)

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis

Por Tohmonda, Takahide, Yoda, Masaki, Iwawaki, Takao, Matsumoto, Morio, Nakamura, Masaya, Mikoshiba, Katsuhiko, Toyama, Yoshiaki, Horiuchi, Keisuke
Publicado no J Clin Invest (2015)

The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control

Por Athanasiou, Dimitra, Bevilacqua, Dalila, Aguila, Monica, McCulley, Caroline, Kanuga, Naheed, Iwawaki, Takao, Paul Chapple, J., Cheetham, Michael E.
Publicado no Hum Mol Genet (2014)

Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress

Por Nakato, Ryosuke, Ohkubo, Yu, Konishi, Akari, Shibata, Mari, Kaneko, Yuki, Iwawaki, Takao, Nakamura, Tomohiro, Lipton, Stuart A., Uehara, Takashi
Publicado no Sci Rep (2015)

Negative feedback by IRE1β optimizes mucin production in goblet cells

Por Tsuru, Akio, Fujimoto, Naoko, Takahashi, Satsuki, Saito, Michiko, Nakamura, Daisuke, Iwano, Megumi, Iwawaki, Takao, Kadokura, Hiroshi, Ron, David, Kohno, Kenji
Publicado em 2013

2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying Mechanisms

Por Hirai, Shin-ichiro, Kurashima, Hiroaki, Nakamura, Daisuke, Komatsu, Tomoko, Yasuda, Yuki, Habashita-Obata, Sayo, Ichikawa, Sanae, Katsuta, Osamu, Iwawaki, Takao, Kohno, Kenji
Publicado no J Ocul Pharmacol Ther (2015)

Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo

Por Iwawaki, Takao, Akai, Ryoko, Oikawa, Daisuke, Toyoshima, Takae, Yoshino, Mayuko, Suzuki, Mitsumi, Takeda, Naoki, Ishikawa, Tomo-o, Kataoka, Yosky, Yamamura, Ken-ichi
Publicado no Sci Rep (2015)

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

Por Hur, Kyu Yeon, So, Jae-Seon, Ruda, Vera, Frank-Kamenetsky, Maria, Fitzgerald, Kevin, Koteliansky, Victor, Iwawaki, Takao, Glimcher, Laurie H., Lee, Ann-Hwee
Publicado em 2012

In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse

Por Alavi, Marcel V., Chiang, Wei-Chieh, Kroeger, Heike, Yasumura, Douglas, Matthes, Michael T., Iwawaki, Takao, LaVail, Matthew M., Gould, Douglas B., Lin, Jonathan H.
Publicado no Invest Ophthalmol Vis Sci (2015)

Saturated fatty acids engage an IRE1α-dependent pathway to activate the NLRP3 inflammasome in myeloid cells

Por Robblee, Megan M., Kim, Charles C., Abate, Jess Porter, Valdearcos, Martin, Sandlund, Karin L.M., Shenoy, Meera, Volmer, Romain, Iwawaki, Takao, Koliwad, Suneil K.
Publicado no Cell Rep (2016)

The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

Por Tohmonda, Takahide, Miyauchi, Yoshiteru, Ghosh, Rajarshi, Yoda, Masaki, Uchikawa, Shinichi, Takito, Jiro, Morioka, Hideo, Nakamura, Masaya, Iwawaki, Takao, Chiba, Kazuhiro, Toyama, Yoshiaki, Urano, Fumihiko, Horiuchi, Keisuke
Publicado em 2011

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice

Por So, Jae-Seon, Hur, Kyu Yeon, Tarrio, Margarite, Ruda, Vera, Frank-Kamenetsky, Maria, Fitzgerald, Kevin, Koteliansky, Victor, Lichtman, Andrew H., Iwawaki, Takao, Glimcher, Laurie H., Lee, Ann-Hwee
Publicado em 2012

ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

Por Niederreiter, Lukas, Fritz, Teresa M.J., Adolph, Timon E., Krismer, Anna-Maria, Offner, Felix A., Tschurtschenthaler, Markus, Flak, Magdalena B., Hosomi, Shuhei, Tomczak, Michal F., Kaneider, Nicole C., Sarcevic, Edina, Kempster, Sarah L., Raine, Tim, Esser, Daniela, Rosenstiel, Philip, Kohno, Kenji, Iwawaki, Takao, Tilg, Herbert, Blumberg, Richard S., Kaser, Arthur
Publicado em 2013