Microsomal Triglyceride Transfer Protein Inhibition Induces Endoplasmic Reticulum Stress and Increases Gene Transcription via Ire1α/cJun to Enhance Plasma ALT/AST

Microsomal triglyceride transfer protein (MTP) is a target to reduce plasma lipids because of its indispensable role in triglyceride-rich lipoprotein biosynthesis. MTP inhibition in Western diet fed mice decreased plasma triglycerides/cholesterol, whereas increasing plasma alanine/aspartate aminotra...

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Detalhes bibliográficos
Main Authors: Josekutty, Joby, Iqbal, Jahangir, Iwawaki, Takao, Kohno, Kenji, Hussain, M. Mahmood
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656292/
https://ncbi.nlm.nih.gov/pubmed/23532846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.459602
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