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Saturated fatty acids engage an IRE1α-dependent pathway to activate the NLRP3 inflammasome in myeloid cells
Diets rich in saturated fatty acids (SFAs) produce a form of tissue inflammation driven by “metabolically activated” macrophages. We show that SFAs, when in excess, induce a unique transcriptional signature in both mouse and human macrophages that is enriched for a subset of ER stress markers, parti...
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| Pubblicato in: | Cell Rep |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5242525/ https://ncbi.nlm.nih.gov/pubmed/26971994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.053 |
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