Saturated fatty acids engage an IRE1α-dependent pathway to activate the NLRP3 inflammasome in myeloid cells

Diets rich in saturated fatty acids (SFAs) produce a form of tissue inflammation driven by “metabolically activated” macrophages. We show that SFAs, when in excess, induce a unique transcriptional signature in both mouse and human macrophages that is enriched for a subset of ER stress markers, parti...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Robblee, Megan M., Kim, Charles C., Abate, Jess Porter, Valdearcos, Martin, Sandlund, Karin L.M., Shenoy, Meera, Volmer, Romain, Iwawaki, Takao, Koliwad, Suneil K.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242525/
https://ncbi.nlm.nih.gov/pubmed/26971994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.053
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