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The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control
Mutations in rhodopsin, the light-sensitive protein of rod cells, are the most common cause of autosomal dominant retinitis pigmentosa (ADRP). Many rod opsin mutations, such as P23H, lead to misfolding of rod opsin with detrimental effects on photoreceptor function and viability. Misfolded P23H rod...
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| Pubblicato in: | Hum Mol Genet |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4240209/ https://ncbi.nlm.nih.gov/pubmed/25055872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu385 |
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