The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control

Mutations in rhodopsin, the light-sensitive protein of rod cells, are the most common cause of autosomal dominant retinitis pigmentosa (ADRP). Many rod opsin mutations, such as P23H, lead to misfolding of rod opsin with detrimental effects on photoreceptor function and viability. Misfolded P23H rod...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Athanasiou, Dimitra, Bevilacqua, Dalila, Aguila, Monica, McCulley, Caroline, Kanuga, Naheed, Iwawaki, Takao, Paul Chapple, J., Cheetham, Michael E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240209/
https://ncbi.nlm.nih.gov/pubmed/25055872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu385
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