AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity

Rhodopsin misfolding caused by the P23H mutation is a major cause of autosomal dominant retinitis pigmentosa (adRP). To date, there are no effective treatments for adRP. The BiP co-chaperone and reductase ERdj5 (DNAJC10) is part of the endoplasmic reticulum (ER) quality control machinery, and previo...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Aguilà, Monica, Bellingham, James, Athanasiou, Dimitra, Bevilacqua, Dalila, Duran, Yanai, Maswood, Ryea, Parfitt, David A, Iwawaki, Takao, Spyrou, Giannis, Smith, Alexander J, Ali, Robin R, Cheetham, Michael E
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
General Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254845/
https://ncbi.nlm.nih.gov/pubmed/32196553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa049
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