Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration

Por Ovando-Roche, Patrick, Georgiadis, Anastasios, Smith, Alexander J., Pearson, Rachael A., Ali, Robin R.
Publicado no Curr Stem Cell Rep (2017)

Beluga whale summer habitat associations in the Nelson River estuary, western Hudson Bay, Canada

Por Smith, Alexander J., Higdon, Jeff W., Richard, Pierre, Orr, Jack, Bernhardt, Warren, Ferguson, Steven H.
Publicado no PLoS One (2017)

Calcium-dependent Clustering of Inositol 1,4,5-Trisphosphate Receptors

Por Wilson, Bridget S., Pfeiffer, Janet R., Smith, Alexander J., Oliver, Janet M., Oberdorf, Jon A., Wojcikiewicz, Richard J.H.
Publicado em 1998

Müller Glia Activation in Response to Inherited Retinal Degeneration Is Highly Varied and Disease-Specific

Por Hippert, Claire, Graca, Anna B., Barber, Amanda C., West, Emma L., Smith, Alexander J., Ali, Robin R., Pearson, Rachael A.
Publicado no PLoS One (2015)

Influence of Manatees' Diving on Their Risk of Collision with Watercraft

Por Edwards, Holly H., Martin, Julien, Deutsch, Charles J., Muller, Robert G., Koslovsky, Stacie M., Smith, Alexander J., Barlas, Margaret E.
Publicado no PLoS One (2016)

Reaction Diffusion Modeling of Calcium Dynamics with Realistic ER Geometry

Por Means, Shawn, Smith, Alexander J., Shepherd, Jason, Shadid, John, Fowler, John, Wojcikiewicz, Richard J. H., Mazel, Tomas, Smith, Gregory D., Wilson, Bridget S.
Publicado em 2006

Long-Term Preservation of Cones and Improvement in Visual Function Following Gene Therapy in a Mouse Model of Leber Congenital Amaurosis Caused by Guanylate Cyclase-1 Deficiency

Por Mihelec, Marija, Pearson, Rachael A., Robbie, Scott J., Buch, Prateek K., Azam, Selina A., Bainbridge, James W.B., Smith, Alexander J., Ali, Robin R.
Publicado em 2011

Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization

Por Villacampa, Pilar, Menger, Katja E., Abelleira, Laura, Ribeiro, Joana, Duran, Yanai, Smith, Alexander J., Ali, Robin R., Luhmann, Ulrich F., Bainbridge, James W. B.
Publicado no PLoS One (2017)

Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy

Por Carvalho, Livia S., Xu, Jianhua, Pearson, Rachael A., Smith, Alexander J., Bainbridge, James W., Morris, Lynsie M., Fliesler, Steven J., Ding, Xi-Qin, Ali, Robin R.
Publicado em 2011

Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy

Por Mowat, Freya M., Gonzalez, Francisco, Luhmann, Ulrich F.O., Lange, Clemens A., Duran, Yanai, Smith, Alexander J., Maxwell, Patrick H., Ali, Robin R., Bainbridge, James W.B.
Publicado em 2012

HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia

Por Mowat, Freya M., Luhmann, Ulrich F. O., Smith, Alexander J., Lange, Clemens, Duran, Yanai, Harten, Sarah, Shukla, Deepa, Maxwell, Patrick H., Ali, Robin R., Bainbridge, James W. B.
Publicado em 2010

Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization—Brief Report

Por Liyanage, Sidath E., Fantin, Alessandro, Villacampa, Pilar, Lange, Clemens A., Denti, Laura, Cristante, Enrico, Smith, Alexander J., Ali, Robin R., Luhmann, Ulrich F., Bainbridge, James W., Ruhrberg, Christiana
Publicado no Arterioscler Thromb Vasc Biol (2016)

Gene Therapy with a Promoter Targeting Both Rods and Cones Rescues Retinal Degeneration Caused by AIPL1 Mutations

Por Sun, Xun, Pawlyk, Basil, Xu, Xiaoyun, Liu, Xiaoqing, Bulgakov, Oleg, Adamian, Michael, Sandberg, Michael A., Khani, Shahrokh C., Tan, Mei-Hong, Smith, Alexander J., Ali, Robin R., Li, Tiansen
Publicado em 2009

Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV...

Por Tan, Mei Hong, Smith, Alexander J., Pawlyk, Basil, Xu, Xiaoyun, Liu, Xiaoqing, Bainbridge, James B., Basche, Mark, McIntosh, Jenny, Tran, Hoai Viet, Nathwani, Amit, Li, Tiansen, Ali, Robin R.
Publicado em 2009

Lentiviral-Vector Mediated Expression of Murine IL-1 Receptor Antagonist or IL-10 Reduces the Severity of Endotoxin-Induced Uveitis

Por Trittibach, Peter, Barker, Susie E, Broderick, Cathryn A, Natkunarajah, Mythili, Duran, Yanai, Robbie, Scott J, Bainbridge, James WB, Smith, Alexander J, Sarra, Gian-Marco, Dick, Andrew D, Ali, Robin R
Publicado em 2008

Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV...

Por Tan, Mei Hong, Smith, Alexander J., Pawlyk, Basil, Xu, Xiaoyun, Liu, Xiaoqing, Bainbridge, James B., Basche, Mark, McIntosh, Jenny, Tran, Hoai Viet, Nathwani, Amit, Li, Tiansen, Ali, Robin R.
Publicado em 2010

Long-Term Survival of Photoreceptors Transplanted into the Adult Murine Neural Retina Requires Immune Modulation

Por West, Emma L., Pearson, Rachael A., Barker, Susie E., Luhmann, Ulrich F. O., Maclaren, Robert E., Barber, Amanda C., Duran, Yanai, Smith, Alexander J., Sowden, Jane C., Ali, Robin R.
Publicado em 2010

Photoreceptor Rescue by an Abbreviated Human RPGR Gene in a Murine Model of X-linked Retinitis Pigmentosa

Por Pawlyk, Basil S., Adamian, Michael, Sun, Xun, Bulgakov, Oleg V., Shu, Xinhua, Smith, Alexander J., Berson, Eliot L., Ali, Robin R., Khani, Shahrokh, F.Wright, Alan, Sandberg, Michael A., Li, Tiansen
Publicado no Gene Ther (2015)

Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice

Por Barker, Susie E, Broderick, Cathryn A, Robbie, Scott J, Duran, Yanai, Natkunarajah, Mythili, Buch, Prateek, Balaggan, Kamaljit S, MacLaren, Robert E, Bainbridge, James W B, Smith, Alexander J, Ali, Robin R
Publicado em 2009

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model

Por Chu, Colin J., Gardner, Peter J., Copland, David A., Liyanage, Sidath E., Gonzalez-Cordero, Anai, kleine Holthaus, Sophia-Martha, Luhmann, Ulrich F. O., Smith, Alexander J., Ali, Robin R., Dick, Andrew D.
Publicado no Dis Model Mech (2016)