The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control

Mutations in rhodopsin, the light-sensitive protein of rod cells, are the most common cause of autosomal dominant retinitis pigmentosa (ADRP). Many rod opsin mutations, such as P23H, lead to misfolding of rod opsin with detrimental effects on photoreceptor function and viability. Misfolded P23H rod...

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Bibliografske podrobnosti
izdano v:Hum Mol Genet
Main Authors: Athanasiou, Dimitra, Bevilacqua, Dalila, Aguila, Monica, McCulley, Caroline, Kanuga, Naheed, Iwawaki, Takao, Paul Chapple, J., Cheetham, Michael E.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240209/
https://ncbi.nlm.nih.gov/pubmed/25055872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu385
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