BiP prevents rod opsin aggregation

Mutations in rod opsin—the light-sensitive protein of rod cells—cause retinitis pigmentosa. Many rod opsin mutations lead to protein misfolding, and therefore it is important to understand the role of molecular chaperones in rod opsin biogenesis. We show that BiP (HSPA5) prevents the aggregation of...

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Huvudupphovsmän: Athanasiou, Dimitra, Kosmaoglou, Maria, Kanuga, Naheed, Novoselov, Sergey S., Paton, Adrienne W., Paton, James C., Chapple, J. Paul, Cheetham, Michael E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Cell Biology 2012
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442401/
https://ncbi.nlm.nih.gov/pubmed/22855534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-02-0168
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