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IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
The mammalian stress sensor IRE1α plays a central role in the unfolded protein, or endoplasmic reticulum (ER), stress response by activating its downstream transcription factor XBP1 via an unconventional splicing mechanism. IRE1α can also induce the degradation of a subset of mRNAs in a process term...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280871/ https://ncbi.nlm.nih.gov/pubmed/22291093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111298 |
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