In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse

PURPOSE: Endoplasmic reticulum (ER) stress activates inositol requiring enzyme 1 (IRE1), a key regulator of the unfolded protein response. The ER stress activated indicator (ERAI) transgenic mouse expresses a yellow fluorescent GFP variant (Venus) when IRE1 is activated by ER stress. We tested wheth...

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Detalles Bibliográficos
Publicado en:Invest Ophthalmol Vis Sci
Autores principales: Alavi, Marcel V., Chiang, Wei-Chieh, Kroeger, Heike, Yasumura, Douglas, Matthes, Michael T., Iwawaki, Takao, LaVail, Matthew M., Gould, Douglas B., Lin, Jonathan H.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2015
Materias:
Retinal Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627472/
https://ncbi.nlm.nih.gov/pubmed/26513501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16969
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