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Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration
Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the Unfolded Protein Response (UPR). The pathop...
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| Publicado no: | Mol Neurobiol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4383737/ https://ncbi.nlm.nih.gov/pubmed/25270370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-014-8881-8 |
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