Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration

Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the Unfolded Protein Response (UPR). The pathop...

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Dades bibliogràfiques
Publicat a:Mol Neurobiol
Autors principals: Chiang, Wei-Chieh, Kroeger, Heike, Sakami, Sanae, Messah, Carissa, Yasumura, Douglas, Matthes, Michael T., Coppinger, Judith A., Palczewski, Krzysztof, LaVail, Matthew M., Lin, Jonathan H.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383737/
https://ncbi.nlm.nih.gov/pubmed/25270370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-014-8881-8
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