Small Molecule Proteostasis Regulators for Protein Conformational Diseases

Protein homeostasis (proteostasis) is essential for cellular and organismal health. Stress, aging, and the chronic expression of misfolded proteins, however, challenge the proteostasis machinery and the vitality of the cell. Enhanced expression of molecular chaperones, regulated by heat shock transc...

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Detalhes bibliográficos
Main Authors: Calamini, Barbara, Silva, Maria Catarina, Madoux, Franck, Hutt, Darren M., Khanna, Shilpi, Chalfant, Monica A., Saldanha, Sanjay A., Hodder, Peter, Tait, Bradley D., Garza, Dan, Balch, William E., Morimoto, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262058/
https://ncbi.nlm.nih.gov/pubmed/22198733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.763
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