Expanding Proteostasis by Membrane Trafficking Networks

מאת Hutt, Darren M., Balch, William E.
יצא לאור 2013

The Proteostasis Boundary in Misfolding Diseases of Membrane Traffic

מאת Hutt, Darren M., Powers, Evan T., Balch, William E.
יצא לאור 2009

HDAC inhibitors rescue multiple disease-causing CFTR variants

מאת Anglès, Frédéric, Hutt, Darren M, Balch, William E
הוצא לאור ב Hum Mol Genet (2019)

Emergent Properties of Proteostasis in Managing Cystic Fibrosis

מאת Balch, William E., Roth, Daniela M., Hutt, Darren M.
יצא לאור 2011

A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease

מאת Hutt, Darren M, Loguercio, Salvatore, Campos, Alexandre Rosa, Balch, William E
הוצא לאור ב J Mol Biol (2018)

The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition

מאת Hutt, Darren M., Roth, Daniela Martino, Vignaud, Hélène, Cullin, Christophe, Bouchecareilh, Marion
יצא לאור 2014

Histone Deacetylase Inhibitor (HDACi) Suberoylanilide Hydroxamic Acid (SAHA)-mediated Correction of α1-Antitrypsin Deficiency

מאת Bouchecareilh, Marion, Hutt, Darren M., Szajner, Patricia, Flotte, Terence R., Balch, William E.
יצא לאור 2012

Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3–mediated translation initiation

מאת Hutt, Darren M., Loguercio, Salvatore, Roth, Daniela Martino, Su, Andrew I., Balch, William E.
הוצא לאור ב J Biol Chem (2018)

Correction of Niemann-Pick type C1 trafficking and activity with the histone deacetylase inhibitor valproic acid

מאת Subramanian, Kanagaraj, Hutt, Darren M., Scott, Samantha M., Gupta, Vijay, Mao, Shu, Balch, William E.
הוצא לאור ב J Biol Chem (2020)

A Chaperone Trap Contributes to the Onset of Cystic Fibrosis

מאת Coppinger, Judith A., Hutt, Darren M., Razvi, Abbas, Koulov, Atanas V., Pankow, Sandra, Yates, John R., Balch, William E.
יצא לאור 2012

FK506 Binding Protein 8 Peptidylprolyl Isomerase Activity Manages a Late Stage of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Folding and Stability

מאת Hutt, Darren M., Roth, Daniela Martino, Chalfant, Monica A., Youker, Robert T., Matteson, Jeanne, Brodsky, Jeffrey L., Balch, William E.
יצא לאור 2012

Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy

מאת Hutt, Darren M., Mishra, Sanjay Kumar, Roth, Daniela Martino, Larsen, Mads Breum, Angles, Frédéric, Frizzell, Raymond A., Balch, William E.
הוצא לאור ב J Biol Chem (2018)

Individualized management of genetic diversity in Niemann-Pick C1 through modulation of the Hsp70 chaperone system

מאת Wang, Chao, Scott, Samantha M, Sun, Shuhong, Zhao, Pei, Hutt, Darren M, Shao, Hao, Gestwicki, Jason E, Balch, William E
הוצא לאור ב Hum Mol Genet (2020)

Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells

מאת Pipalia, Nina H., Subramanian, Kanagaraj, Mao, Shu, Ralph, Harold, Hutt, Darren M., Scott, Samantha M., Balch, William E., Maxfield, Frederick R.
הוצא לאור ב J Lipid Res (2017)

Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process

מאת Wang, Chao, Scott, Samantha M., Subramanian, Kanagaraj, Loguercio, Salvatore, Zhao, Pei, Hutt, Darren M., Farhat, Nicole Y., Porter, Forbes D., Balch, William E.
הוצא לאור ב Nat Commun (2019)

Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides That Restore Trafficking and Activity of ΔF508-CFTR

מאת Hutt, Darren M., Olsen, Christian A., Vickers, Chris J., Herman, David, Chalfant, Monica A., Montero, Ana, Leman, Luke J., Burkle, Renner, Maryanoff, Bruce E., Balch, William E., Ghadiri, M. Reza
יצא לאור 2011

Small Molecule Proteostasis Regulators for Protein Conformational Diseases

מאת Calamini, Barbara, Silva, Maria Catarina, Madoux, Franck, Hutt, Darren M., Khanna, Shilpi, Chalfant, Monica A., Saldanha, Sanjay A., Hodder, Peter, Tait, Bradley D., Garza, Dan, Balch, William E., Morimoto, Richard I.
יצא לאור 2011

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

מאת Roth, Daniela Martino, Hutt, Darren M., Tong, Jiansong, Bouchecareilh, Marion, Wang, Ning, Seeley, Theo, Dekkers, Johanna F., Beekman, Jeffrey M., Garza, Dan, Drew, Lawrence, Masliah, Eliezer, Morimoto, Richard I., Balch, William E.
הוצא לאור ב PLoS Biol (2014)

Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone

מאת Singh, Jay K., Hutt, Darren M., Tait, Bradley, Guy, Naihsuan C., Sivils, Jeffrey C., Ortiz, Nina R., Payan, Ashley N, Komaragiri, Shravan Kumar, Owens, Jazzmin Jovonna, Culbertson, David, Blair, Laura J., Dickey, Chad, Kuo, Szu Yu, Finley, Dan, Dyson, H. Jane, Cox, Marc B., Chaudhary, Jaideep, Gestwicki, Jason E., Balch, William E.
הוצא לאור ב Cell Chem Biol (2020)

Reduced Histone Deacetylase 7 Activity Restores Function to Misfolded CFTR in Cystic Fibrosis

מאת Hutt, Darren M., Herman, David, Rodrigues, Ana P. C., Noel, Sabrina, Pilewski, Joseph M., Matteson, Jeanne, Hoch, Ben, Kellner, Wendy, Kelly, Jeffery W., Schmidt, Andre, Thomas, Philip J., Matsumura, Yoshihiro, Skach, William R., Gentzsch, Martina, Riordan, John R., Sorscher, Eric J., Okiyoneda, Tsukasa, Lukacs, Gergely L., Frizzell, Raymond A., Manning, Gerard, Gottesfeld, Joel M., Balch, William E.
יצא לאור 2009