FK506 Binding Protein 8 Peptidylprolyl Isomerase Activity Manages a Late Stage of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Folding and Stability

Cystic fibrosis (CF) is caused by mutations in the apical chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) with 90% of patients carrying at least one deletion of the F508 (ΔF508) allele. This mutant form of CFTR is characterized by a folding and trafficking defect that pre...

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Detalhes bibliográficos
Main Authors: Hutt, Darren M., Roth, Daniela Martino, Chalfant, Monica A., Youker, Robert T., Matteson, Jeanne, Brodsky, Jeffrey L., Balch, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381152/
https://ncbi.nlm.nih.gov/pubmed/22474283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.339788
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