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Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone
Hsp90 plays an important role in health and is a therapeutic target for managing misfolding disease. Compounds that disrupt co-chaperone delivery of clients to Hsp90 target a subset of Hsp90 activities, thereby minimizing the toxicity of pan-Hsp90 inhibitors. Herein, we have identified SEW04784 as a...
Tallennettuna:
| Julkaisussa: | Cell Chem Biol |
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| Päätekijät: | , , , , , , , , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7144688/ https://ncbi.nlm.nih.gov/pubmed/32017918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.01.008 |
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