Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone

Hsp90 plays an important role in health and is a therapeutic target for managing misfolding disease. Compounds that disrupt co-chaperone delivery of clients to Hsp90 target a subset of Hsp90 activities, thereby minimizing the toxicity of pan-Hsp90 inhibitors. Herein, we have identified SEW04784 as a...

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Publicado en:Cell Chem Biol
Main Authors: Singh, Jay K., Hutt, Darren M., Tait, Bradley, Guy, Naihsuan C., Sivils, Jeffrey C., Ortiz, Nina R., Payan, Ashley N, Komaragiri, Shravan Kumar, Owens, Jazzmin Jovonna, Culbertson, David, Blair, Laura J., Dickey, Chad, Kuo, Szu Yu, Finley, Dan, Dyson, H. Jane, Cox, Marc B., Chaudhary, Jaideep, Gestwicki, Jason E., Balch, William E.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144688/
https://ncbi.nlm.nih.gov/pubmed/32017918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.01.008
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