The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost

Por Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no Front Neurosci (2016)

The Earliest Tau Dysfunction in Alzheimer's Disease?: Tau Phosphorylated at S422 as a Toxic Seed

Por Voss, Kellen, Koren, John, Dickey, Chad A.
Publicado em 2011

Reconstructing the Hsp90/Tau Machine

Por Jinwal, Umesh K., Koren, John, Dickey, Chad A.
Publicado em 2013

Potential synergy between tau aggregation inhibitors and tau chaperone modulators

Por Blair, Laura J, Zhang, Bo, Dickey, Chad A
Publicado em 2013

A global view of Hsp90 functions

Por Chiosis, Gabriela, Dickey, Chad A, Johnson, Jill L
Publicado em 2013

Neuronal Lifespan versus Healthspan: Principles of Natural Selection at Work in the Degenerating Brain

Por O’Leary, John C., Koren, John, Dickey, Chad A.
Publicado no J Mol Neurosci (2011)

Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease

Por Blair, Laura J., Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no Expert Opin Ther Targets (2014)

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies

Por Miyata, Yoshinari, Koren, John, Kiray, Janine, Dickey, Chad A, Gestwicki, Jason E
Publicado em 2011

The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing and Alzheimer's disease

Por Blair, Laura J., Baker, Jeremy D., Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no J Neurochem (2015)

Targeting the ER-Autophagy System in the Trabecular Meshwork to Treat Glaucoma

Por Stothert, Andrew R., Fontaine, Sarah N., Sabbagh, Jonathan J., Dickey, Chad A.
Publicado no Exp Eye Res (2015)

Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease

Por Calcul, Laurent, Zhang, Bo, Jinwal, Umesh K, Dickey, Chad A, Baker, Bill J
Publicado em 2012

The role of FKBP5 in mood disorders: Action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance

Por O’Leary, John C., Zhang, Bo, Koren, John, Blair, Laura, Dickey, Chad A.
Publicado no CNS Neurol Disord Drug Targets (2013)

FKBP51 and FKBP52 in Signaling and Disease

Por Storer, Cheryl L., Dickey, Chad A., Galigniana, Mario D., Rein, Theo, Cox, Marc B.
Publicado em 2011

Bending tau into shape: the emerging role of peptidyl prolyl-isomerases in tauopathies

Por Koren, John, Jinwal, Umesh K., Davey, Zachary, Kiray, Janine, Arulselvam, Karthik, Dickey, Chad A.
Publicado em 2011

Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold

Por Mishra, Sanket J., Ghosh, Suman, Stothert, Andrew R., Dickey, Chad A., Blagg, Brian S. J.
Publicado no ACS Chem Biol (2016)

Identification of Dihydropyridines That Reduce Cellular Tau Levels

Por Evans, Christopher G., Jinwal, Umesh K., Makley, Leah N., Dickey, Chad A., Gestwicki, Jason E.
Publicado em 2010

Chaperones in Neurodegeneration

Por Lindberg, Iris, Shorter, James, Wiseman, R. Luke, Chiti, Fabrizio, Dickey, Chad A., McLean, Pamela J.
Publicado no J Neurosci (2015)

MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation

Por Zheng, Dali, Sabbagh, Jonathan J., Blair, Laura J., Darling, April L., Wen, Xiaoqi, Dickey, Chad A.
Publicado no J Biol Chem (2016)

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice

Por Dickey, Chad A, Gordon, Marcia N, Wilcock, Donna M, Herber, Donna L, Freeman, Melissa J, Morgan, Dave
Publicado em 2005

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

Por Dickey, Chad A, Ash, Peter, Klosak, Natalia, Lee, Wing C, Petrucelli, Leonard, Hutton, Michael, Eckman, Christopher B
Publicado em 2006