Expanding the Number of “Druggable” Targets: Non-Enzymes and Protein-Protein Interactions

по Makley, Leah N., Gestwicki, Jason E.
Опубликовано 2013

The other lives of ribosomal proteins

по Bhavsar, Rital B, Makley, Leah N, Tsonis, Panagiotis A
Опубликовано 2010

Genomic Heat Shock Element Sequences Drive Cooperative Human Heat Shock Factor 1 DNA Binding and Selectivity

по Jaeger, Alex M., Makley, Leah N., Gestwicki, Jason E., Thiele, Dennis J.
Опубликовано 2014

Identification of Dihydropyridines That Reduce Cellular Tau Levels

по Evans, Christopher G., Jinwal, Umesh K., Makley, Leah N., Dickey, Chad A., Gestwicki, Jason E.
Опубликовано 2010

BAG3 is a modular, scaffolding protein that physically links heat shock protein 70 (Hsp70) to the small heat shock proteins

по Rauch, Jennifer N., Tse, Eric, Freilich, Rebecca, Mok, Sue-Ann, Makley, Leah N., Southworth, Daniel R., Gestwicki, Jason E.
Опубликовано в: J Mol Biol (2016)

Chemical Validation of a Druggable Site on Hsp27/HSPB1 using In Silico Solvent Mapping and Biophysical Methods

по Makley, Leah N., Johnson, Oleta T., Ghanakota, Phani, Rauch, Jennifer N., Osborn, Delaney, Wu, Taia, Cierpicki, Tomasz, Carlson, Heather A., Gestwicki, Jason E.
Опубликовано в: Bioorg Med Chem (2021)

Pharmacological Tuning of Heat Shock Protein 70 Modulates Polyglutamine Toxicity and Aggregation

по Chafekar, Sidhartha M., Wisén, Susanne, Thompson, Andrea D., Echeverria, AnaLisa, Walter, Gladis M., Evans, Christopher G., Makley, Leah N., Gestwicki, Jason E., Duennwald, Martin L.
Опубликовано 2012

Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts

по Molnar, Kathleen S., Dunyak, Bryan M., Su, Bonnie, Izrayelit, Yevgeniy, McGlasson-Naumann, Brittney, Hamilton, Paul D., Qian, Mingxing, Covey, Douglas F., Gestwicki, Jason E., Makley, Leah N., Andley, Usha P.
Опубликовано в: Invest Ophthalmol Vis Sci (2019)

Pharmacological Chaperone for Alpha-Crystallin Partially Restores Transparency in Cataract Models

по Makley, Leah N., McMenimen, Kathryn A., DeVree, Brian T., Goldman, Joshua W., McGlasson, Brittney N., Rajagopal, Ponni, Dunyak, Bryan M., McQuade, Thomas J., Thompson, Andrea D., Sunahara, Roger, Klevit, Rachel E., Andley, Usha P., Gestwicki, Jason E.
Опубликовано в: Science (2015)