Pharmacological Chaperone for Alpha-Crystallin Partially Restores Transparency in Cataract Models

Cataracts reduce vision in 50% of individuals over 70 years of age and are a common form of blindness worldwide. Cataracts are caused when damage to the major lens crystallin proteins causes their misfolding and aggregation into insoluble amyloids. Using a thermal stability assay, we identified a cl...

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Udgivet i:Science
Main Authors: Makley, Leah N., McMenimen, Kathryn A., DeVree, Brian T., Goldman, Joshua W., McGlasson, Brittney N., Rajagopal, Ponni, Dunyak, Bryan M., McQuade, Thomas J., Thompson, Andrea D., Sunahara, Roger, Klevit, Rachel E., Andley, Usha P., Gestwicki, Jason E.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725592/
https://ncbi.nlm.nih.gov/pubmed/26542570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac9145
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