Pharmacological Chaperone for Alpha-Crystallin Partially Restores Transparency in Cataract Models

Cataracts reduce vision in 50% of individuals over 70 years of age and are a common form of blindness worldwide. Cataracts are caused when damage to the major lens crystallin proteins causes their misfolding and aggregation into insoluble amyloids. Using a thermal stability assay, we identified a cl...

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Publicado en:Science
Main Authors: Makley, Leah N., McMenimen, Kathryn A., DeVree, Brian T., Goldman, Joshua W., McGlasson, Brittney N., Rajagopal, Ponni, Dunyak, Bryan M., McQuade, Thomas J., Thompson, Andrea D., Sunahara, Roger, Klevit, Rachel E., Andley, Usha P., Gestwicki, Jason E.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725592/
https://ncbi.nlm.nih.gov/pubmed/26542570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac9145
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