Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts

PURPOSE: We previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind and stabilize αB-crystallin (cryAB) in vitro a...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Molnar, Kathleen S., Dunyak, Bryan M., Su, Bonnie, Izrayelit, Yevgeniy, McGlasson-Naumann, Brittney, Hamilton, Paul D., Qian, Mingxing, Covey, Douglas F., Gestwicki, Jason E., Makley, Leah N., Andley, Usha P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2019
Assuntos:
Lens
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676924/
https://ncbi.nlm.nih.gov/pubmed/31369034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.18-25647
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