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The Earliest Tau Dysfunction in Alzheimer's Disease?: Tau Phosphorylated at S422 as a Toxic Seed

In this Commentary, Voss and colleagues discuss the work of Vana et al. who show that tau phosphorlyated at S422 in the cholinergic basal forebrain is the earliest marker of tau pathogenesis. The ramifications of these findings for future drug development specifically for tauopathies and Alzheimer&#...

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Bibliografiske detaljer
Main Authors: Voss, Kellen, Koren, John, Dickey, Chad A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204013/
https://ncbi.nlm.nih.gov/pubmed/21964186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.020
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