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The Earliest Tau Dysfunction in Alzheimer's Disease?: Tau Phosphorylated at S422 as a Toxic Seed
In this Commentary, Voss and colleagues discuss the work of Vana et al. who show that tau phosphorlyated at S422 in the cholinergic basal forebrain is the earliest marker of tau pathogenesis. The ramifications of these findings for future drug development specifically for tauopathies and Alzheimer&#...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3204013/ https://ncbi.nlm.nih.gov/pubmed/21964186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.020 |
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