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Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold

Glucose regulated protein 94 kDa, Grp94, is the endoplasmic reticulum (ER) localized isoform of heat shock protein 90 (Hsp90) that is responsible for the trafficking and maturation of toll-like receptors, immunoglobulins, and integrins. As a result, Grp94 has emerged as a therapeutic target to disru...

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Bibliografische gegevens
Gepubliceerd in:ACS Chem Biol
Hoofdauteurs: Mishra, Sanket J., Ghosh, Suman, Stothert, Andrew R., Dickey, Chad A., Blagg, Brian S. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568423/
https://ncbi.nlm.nih.gov/pubmed/27959508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00747
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