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Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold

Glucose regulated protein 94 kDa, Grp94, is the endoplasmic reticulum (ER) localized isoform of heat shock protein 90 (Hsp90) that is responsible for the trafficking and maturation of toll-like receptors, immunoglobulins, and integrins. As a result, Grp94 has emerged as a therapeutic target to disru...

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Détails bibliographiques
Publié dans:ACS Chem Biol
Auteurs principaux: Mishra, Sanket J., Ghosh, Suman, Stothert, Andrew R., Dickey, Chad A., Blagg, Brian S. J.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568423/
https://ncbi.nlm.nih.gov/pubmed/27959508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00747
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